PCV20 includes all 13 serotypes in PCV13, along with seven additional serotypes “that are responsible for a substantial amount of the residual disease burden,” he added.

The randomised, double-blind, active-controlled Phase II study compared the vaccine’s tolerability, immunogenicity, and safety against Prevnar 20 (PCV20) in healthy infants.

V116 was non-inferior to PCV20 for the 10 serotypes common to both vaccines (3, 6A, 7F, 8, 10A, 11A, 12F, 19A, 22F, 33F), as assessed by serotype-specific OPA GMTs 30 days post-vaccination.

At the 2.2mcg dose, VAX-24 met the standard OPA response non-inferiority criteria (1) for all 20 serotypes common with PCV20, of which 16 serotypes (3, 4, 6B, 7F, 8, 9V, 10A, 11A, 12F, 14, 15B ...

At the 2.2 mcg dose, VAX-24 met the standard OPA response non-inferiority criteria (1) for all 20 serotypes common with PCV20, of which 16 serotypes (3, 4, 6B, 7F, 8, 9V, 10A, 11A, 12F, 14, 15B ...

The 20-valent pneumococcal conjugate vaccine (PCV20, or Prevnar 20) produced a non-inferior immune response in adults to the 13-valent vaccine (PCV13, or Prevnar 13), with an adequate safety ...

They can get PCV20 or PCV21 if they have received both: -- PCV13 (but not PCV15, PCV20, or PCV21) at any age, and -- PPSV23 at or after the age of 65.

At the middle and high doses, VAX-31 met or exceeded the OPA response non-inferiority criteria for all 20 serotypes common with PCV20. Vaxcyte plans to initiate a Phase 3 study by mid-2025 and ...

The recommendation would leave the choice of PCV up to the clinician. The updated language calls for a single dose of PCV (which could be PCV15, PCV20, or PCV21) for all adults aged 50 years or ...

Superior immune responses were also observed for 10 of 11 serotypes included in V116 but not in PCV20 (9N, 15A, 16F, 17, 20A, 23A, 23B, 24F, 31, 35B).

At the 2.2mcg dose, VAX-24 met the standard OPA response non-inferiority criteria (1) for all 20 serotypes common with PCV20, of which 16 serotypes (3, 4, 6B, 7F, 8, 9V, 10A, 11A, 12F, 14, 15B ...