Plants produce a wide diversity of compounds. Broadly, these are separated into primary metabolites, which are necessary for ...

Single cells are typically typed by clustering into discrete locations in reduced dimensional transcriptome space. Here we introduce Stator, a data-driven method that identifies cell (sub)types and ...

To our knowledge, no systematic effort to understand the mechanisms behind paralog compensation has been undertaken in the context of cancer or human cells. However, there have been a number of ...

Immunomodulatory imide drugs (IMiDs) degrade specific C2H2 zinc finger degrons in transcription factors, making them effective against certain cancers. SALL4, a cancer driver, contains seven C2H2 zinc ...

DNMT3A mutations may also have hitherto unrecognised non-canonical functions in HSCs. TP53 in humans, or Trp53 in mice (generally referred to as p53 throughout this text) is a key tumour suppressor ...

Spatial proteomics (SP) encompasses a diverse array of technologies that vary in scale, resolution, and sensitivity, offering researchers and clinicians a broad range of tools to investigate the ...

Signaling pathways play a major role in P-body dynamics and different protein kinases have been functionally associated with the regulation of P-body assembly/disassembly (Rzeczkowski et al, 2011; ...

After the Covid-19 pandemic, pertussis has made a spectacular comeback in Europe and many other parts of the world, while during the pandemic it had essentially disappeared because of the social ...

Here, we report that nTRIP6 is expressed by alternative translation initiation at an internal AUG and that a short open reading frame (ORF) within the Trip6 coding sequence represses nTRIP6 ...

The SCF (SKP1/CUL1/F-box protein) ubiquitin ligase complex plays a protective role against external stress, such as ultraviolet irradiation. The emergence of substrates activates SCF through ...

Chromosome segregation relies on kinetochores that assemble on specialized centromeric chromatin containing a histone H3 variant. In budding yeast, a single centromeric nucleosome containing Cse4 ...

A peculiar case of re-initiation-competent uORFs that has been studied contains only a single amino acid—i.e. the start codon—immediately followed by a stop codon (termed ‘1-aa uORF’ or ‘start-stop ...