An understanding of the global patterns of loss of heterozygosity in a neoplasm is achieved by analysis of polymorphic markers, or allelotyping, which is essential for both identification of new tumor ...

Mutations have been the driving force behind some of the most important discoveries in immunology, and the growing speed with which they can be found has impelled the use of random mutagenesis to ...

This study offers important insight into the pathogenic basis of intragenic frameshift deletions in the carboxy-terminal domain of MECP2, which account for some Rett syndrome cases, yet similar ...