eLife18h
Methylation Clocks Do Not Predict Age or Alzheimer’s Disease Risk Across Genetically Admixed Individuals
Epigenetic clocks that quantify rates of aging from DNA methylation patterns across the genome have emerged as a potential biomarker for risk of age-related diseases, like Alzheimer’s disease (AD), ...
eLife18h
Molecular Feature-Based Classification of Retroperitoneal Liposarcoma: A Prospective Cohort Study
Department of Retroperitoneal Tumor Surgery, Peking University International Hospital, Beijing, China ...
eLife1d
Early Diagnosis and Prognostic Prediction of Colorectal Cancer through Plasma Methylation Regions
The methylation of plasma cell-free DNA (cfDNA) has emerged as a valuable diagnostic and prognostic biomarker in various cancers including colorectal cancer (CRC). Currently, there are no biomarkers ...
eLife1d
Volume electron microscopy reveals unique laminar synaptic characteristics in the human entorhinal cortex
The entorhinal cortex (EC) plays a pivotal role in memory function and spatial navigation, connecting the hippocampus with the neocortex. The EC integrates a wide range of cortical and subcortical ...
eLife2d
PEBP1 amplifies mitochondrial dysfunction-induced integrated stress response
A thermal stability-based proteomic analysis identifies cytoplasmic PEBP1 as a mediator of mitochondrial dysfunction-induced stress response, highlighting its potential role in cellular adaptation ...
eLife2d
Special Issue: Reproductive health
The articles in this special issue highlight the diversity and complexity of research into reproductive health, including the need for a better understanding of the fundamental biology of reproduction ...
eLife2d
Disentangling acute motor deficits and adaptive responses evoked by the loss of cerebellar output
Cerebellar patients exhibit various motor impairments, but the sequence of primary and compensatory processes leading to these deficits remains unclear. To investigate this, we reversibly blocked ...
eLife2d
Citalopram exhibits immune-dependent anti-tumor effects by modulating C5aR1 + TAMs and CD8 + T cells
This important study provides solid evidence to support the anti-tumor potential of citalopram, originally an anti-depression drug, in hepatocellular carcinoma (HCC). In addition to their previous ...
eLife3d
mTOR inhibition in Q175 Huntington’s disease model mice facilitates neuronal autophagy and mutant huntingtin clearance
This study presents a valuable finding on the alterations in the autophagic-lysosomal pathway in a Huntington's disease model. The evidence supporting the claims of the authors is solid. However, the ...
eLife3d
Development of D-box peptides to inhibit the Anaphase Promoting Complex/Cyclosome
Here we explore peptide inhibitors of Cdc20, a substrate-recognition subunit and activator of the E3 ubiquitin ligase the anaphase promoting complex/cyclosome (APC/C) that is essential in mitosis and ...
eLife4d
Neuronal Detection Triggers Systemic Digestive Shutdown in Response to Adverse Food Sources
Southwest United Graduate School, Yunnan Key Laboratory of Cell Metabolism and Diseases, State Key Laboratory of Conservation and Utilization of Bio-resources in Yunnan Center for Life Sciences, ...
eLife2d
Developmental oligodendrocytes regulate brain function through the mediation of synchronized spontaneous activity
In this valuable manuscript, authors ablate cerebellar oligodendrocytes during postnatal development and show that synchrony of calcium transients in Purkinje neurons and behaviours are affected even ...