Epigenetics is the study of various heritable alterations that control gene expression without changing the DNA sequence. 1 The name epigenetics comes from the Greek prefix “epi”, which means on top ...

Timothy Frei, Ching-Hsiang Chang, Maurice Filo, Asterios Arampatzis, Mustafa Khammash, A genetic mammalian proportional–integral feedback control circuit for robust and precise gene regulation, ...

Most people recognize Alzheimer's from its devastating symptoms such as memory loss, while new drugs target pathological aspects of disease manifestations, such as plaques of amyloid proteins. Now a ...

The duration of expression of the gene Cdx2 is tightly regulated by a newly identified DNA sequence element called an “attenuator.” ...

Other major regulators of gene expression—including proteins involved in stress responses, stem cell maintenance and cancer progression—also rely on beta-catenin to link up with BAF.

More information: Itsuki Abe et al, Split RNA switch orchestrates pre- and post-translational control to enable cell type-specific gene expression, Nature Communications (2025).

The expression of genes has to be carefully regulated in cells; active genes give cells their identity and ability to function. Epigenetic features are just one way that cells control gene expression, ...

“This is the first detailed study of how and where ORC regulates epigenetics and gene expression in human cells,” said Anindya Dutta, Ph.D., leader of the study and chair of the University of Alabama ...

Origin-recognition complex (ORC) plays an unexpectedly broad role in the regulation of human cell gene expression, according to a study in the journal Cell Reports.