The caspases are a family of cytosolic proteases with essential roles in inflammation and apoptosis. Drug discovery efforts have focused on developing molecules directed against the active sites of ...

† Most-abundant zymogen granule proteins. ‡ Different isoforms present in zymogen granules. § Validated by morphological studies after identification by mass spectrometry. As the molecular mechanisms ...

Using state-of-the-art robotic and x-ray crystallographic equipment, researchers have revealed for the first time the molecular structure of the zymogen, or inactive, form of a blood-clotting enzyme.

To facilitate expression, the zymogen used in this investigation had the prosegment truncated to 48 residues (numbered 77p–124p), approximately the same size as the prosegments of the archetypal ...

DALLAS, Jan. 18, 2017 - UT Southwestern Medical Center researchers have uncovered the mechanism by which the stress hormone FGF21 keeps digestive enzymes from damaging the pancreas. The research, ...

CAMBRIDGE, Mass. & SALISBURY, England--(BUSINESS WIRE)--KalVista Pharmaceuticals, Inc. (NASDAQ: KALV), a clinical stage pharmaceutical company focused on the discovery, development, and ...

ST. LOUIS – Using state-of-the-art robotic and x-ray crystallographic equipment, researchers at Saint Louis University have revealed for the first time the molecular structure of the zymogen, or ...