The therapeutic action of drugs is predicated on their physical engagement with cellular targets. Here we describe a broadly applicable method using bioluminescence resonance energy transfer (BRET) to ...

In drug discovery, researchers think a lot about how tightly a small molecule binds to its target. For a long time, drug developers have considered tightly binding compounds better, more promising ...

When a drug molecule binds to its target protein, it stays bound for some time before eventually unbinding the target. The actual time how long a drug molecule resides bound to its target varies among ...

A new study helps to explain what defines how long a drug molecule stays bound to its target. A new study from the University of Eastern Finland and the University of Tübingen helps to explain what ...