A research team of the University Medical Center Mainz has succeeded in observing for the first time how G protein-coupled ...

Drug discovery is shifting from static snapshots to moving pictures. Instead of inferring how medicines work from end results ...

Many people are familiar with histamine, a biological molecule that serves as a key driver of allergic reactions and other ...

Psychedelics, psychoactive substances that alter people's perceptions, mood and thought patterns, have recently shown promise ...

Receptor protein tyrosine phosphatases are cell membrane-localized proteins. They are regulators of cell–cell contacts and are also considered likely to be tumor suppressors but how they function is ...

A deep dive into the Fc–FcR axis as a therapeutic anchor in autoimmune disease, examining immune signaling and drug ...

Two different versions of the mu-opioid receptor within a cellular membrane illustrate how the receptor changes its conformation to send a signal into the cell. Scientists captured six high-resolution ...

Taste, pain, or response to stress — nearly all essential functions in the human body are regulated by molecular switches called G protein-coupled receptors (GPCRs). Researchers at the University of ...

Scientists from A*STAR Institute of Molecular and Cell Biology (A*STAR IMCB) have identified why certain lung cancer cells become highly resistant to treatment after developing mutations in a key gene ...

Hitting targets embedded within the cell membrane has long been difficult for drug developers due to the membrane's challenging biochemical properties. Now, chemists have demonstrated new ...