Membrane protein targeting and insertion is a fundamental process in cellular biology that ensures proteins are correctly delivered to, and integrated within, the lipid bilayer. Proteins destined for ...

Molecular glues are enjoying the spotlight, but discovering new ones is often a matter of luck. A new method, developed by ...

Cellular membrane proteins play important roles in cellular transport, signaling, and cell-to-cell communication. Malfunction in membrane proteins can lead to serious diseases, such as cancer. However ...

Origami is collaborating with Ipsen to develop molecules designed to remove or correct abnormal proteins in neurodegenerative diseases.

An estimated 20 percent of adults in the US experience chronic pain. 1 To help patients manage their condition, clinicians have employed one main type of pain-relieving drug: opioids. With their ...

For decades, researchers have worked to untangle the biological causes of neurodegenerative conditions such as Alzheimer’s disease. A primary focus has been the accumulation of misfolded proteins that ...

Chronic diseases such as type 2 diabetes and inflammatory disorders are a major cause of disease burden and deaths around the world, but their treatment has proven difficult because there may not be ...

Researchers have identified a protein that links brain immune activity, metabolism, and amyloid clearance, suggesting a new ...