The receptor tyrosine kinase-like orphan 1 (ROR1) is a transmembrane protein expressed during embryonic development. Moreover, it is highly expressed on the surface of several cancer cell types, ...
Bristol Myers Squibb Co. has identified proteolysis targeting chimera (PROTAC) compounds comprising a E3 ubiquitin ligase-binding moiety coupled to a proto-oncogene tyrosine-protein kinase receptor ...
Researchers at the Kanazawa University Graduate School of Medical Sciences report in PLOS Pathogens a novel role for the ...
Scientists at St. Jude Children's Research Hospital have characterized a hidden intermediate state at the center of Src ...
Clinical Trials Arena on MSN
Hutchmed begins Phase I HMPL-A251 clinical development programme
The clinical study is divided into two parts: a Phase I dose escalation stage and a Phase IIa dose expansion and optimisation stage.
News Medical on MSN
Invisible Kinase State Unveiled for Key Biological Role
December 18, 2025) Scientists at St. Jude Children's Research Hospital have characterized a hidden intermediate state at the center ...
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