Pyruvate dehydrogenase complex (PDC) deficiency is a mitochondrial disorder arising from loss-of-function alterations in the multienzyme assembly that converts glycolytic pyruvate into acetyl-CoA, the ...
Cancer cells often reprogramme energy metabolism to support rapid proliferation and survival under stress. Central to this shift is the pyruvate dehydrogenase complex (PDC), a mitochondrial ...
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