C&EN

Taking Shots On A Signaling Goal

Bayer Healthcare spent 20 years to get from discovery to approval of the first in a class of modulators of the enzyme known as soluble guanylate cyclase, or sGC. In 2013, the Food & Drug ...
Business Wire

Ironwood Pharmaceuticals to Highlight Clinical and Preclinical Data for Praliciguat at the American Diabetes Association’s 78 th Scientific Sessions

sGC plays an important role in regulating many critical physiological processes; therefore dysregulation of sGC may play a role in multiple serious diseases. Ironwood’s sGC stimulators, including ...
Business Wire

Ironwood Pharmaceuticals Initiates Phase II Clinical Trial of sGC Stimulator IW-1701 in Patients with Sickle Cell Disease

IW-1701 has been shown in non-clinical studies to modulate the nitric oxide/soluble guanylate cyclase/cyclic guanosine monophosphate (NO/sGC/cGMP) signaling pathway, which is believed to be implicated ...
Nasdaq

Cyclerion Announces Publication of Preclinical Data Demonstrating Reduction in Neuroinflammation by Brain-Penetrant sGC Stimulator

CAMBRIDGE, Mass., Sept. 22, 2021 (GLOBE NEWSWIRE) -- Cyclerion Therapeutics, Inc. (Nasdaq: CYCN), a clinical-stage biopharmaceutical company developing treatments that restore cognitive function, ...
FierceBiotech

Cyclerion drug's 4-pronged cracking of neurodegenerative diseases passes early test

Scientists have been testing various ways to tackle neurodegenerative diseases—blocking the production of toxic proteins, regenerating functional neurons and restoring the brain’s waste-clearing ...
C&EN

Taking Shots On A Signaling Goal

Bayer Healthcare spent 20 years to get from discovery to approval of the first in a class of modulators of the enzyme known as soluble guanylate cyclase, or sGC. In 2013, the Food & Drug ...