Myc dysregulation in activated macrophages impairs antioxidant defenses, locking them in a vicious cycle that amplifies type I interferon signaling, driving hyperinflammation and immunosuppression.
In preclinical models, rat insulinoma‑derived beta‑cell line INS‑1 (INS‑1) cells and mouse islets showed rapid, robust Viperin induction after cytokine exposure.
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