The increasing interest in Bayesian group sequential design is due to its potential to reinforce efficiency in clinical trials, shorten drug development time, and enhance the accuracy of statistical ...

Decline in the use of erythropoiesis-stimulating agents: Long-term effects of regulation, reimbursement, and unfavorable data. Effect of a topoisomerase-1 inhibitor (topotecan) on the efficacy of ...

We conducted a multicenter, open-label, randomized, controlled trial with a two-group, parallel, group-sequential design. During a 6-month run-in phase, supportive care (in particular, blockade of the ...