Scientists have studied molecular interactions in the chaperonin protein GroEL. GroEL is alternately bound and unbound by a co-chaperonin, GroES. Against expectations, the 'football' complex -- where ...

Cells have different kinds of protein machines that fulfill essential functions, like the DNA polymerase complex, the ribosome and molecular chaperone complexes. The GroEL-GroES chaperonin complex of ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, No. 35 (September 2, 2014), pp. 12775-12780 (6 pages) The GroE chaperonins assist substrate protein (SP) ...

The chaperonin GroEL binds nonnative substrate protein in the hydrophobic central cavity of an open ring. ATP and GroES binding to the same ring converts this cavity into an encapsulated, hydrophilic ...

The chaperonin GroEL assists protein folding by binding nonnative forms through exposed hydrophobic surfaces in an open ring and mediating productive folding in an encapsulated hydrophilic chamber ...

Physicists have created a microscopic device to assist biologists in making very fast molecular measurements that aid the understanding of protein folding. This development may help elucidate ...

Cryo-electron tomography, or cryo-ET for short, can be used to visualize and analyze cellular structures in their natural environment. Researchers at the Max Planck Institute of Biochemistry (MPIB) in ...

Cryo-electron tomography (cryo-ET), can be used to visualize and analyze cellular structures in their natural environment. Researchers at the MPI of Biochemistry in Martinsried and the University ...

J. Martin, T. Langer, R. Boteva, A. Schramel, A.L. Horwich, F.-U. Hartl, "Chaperonin-mediated protein folding at the surface of groEL through a `molten globule'-like ...

Kanazawa - Proteins must fold in a specific way to function. This is often assisted by molecular chaperones--small proteins whose job is to help others fold to the right shape. Now, Japanese ...

(Santa Barbara, Calif.) –– Physicists at UC Santa Barbara have created a microscopic device to assist biologists in making very fast molecular measurements that aid the understanding of protein ...