Therapeutics that leverage protein degradation as their primary mechanism of action appear to be a validated new therapeutic modality. The current clinical molecules are focused on degrading ...

Adhesion G protein-coupled receptors have a large extracellular region (shown in green and orange) that extends into space outside the cell. Almost 35% of drugs approved by the Food and Drug ...

Over the last decade, antibodies that block extracellular receptors on our immune cells have redefined the treatment approach for certain cancers. Now, all eyes are on how using the opposite approach ...

1 By the late 1960s, researchers had become aware that this somewhat obscure class of lipids had the remarkable ability to act like an extracellular signaling molecule. 2 Two prominent forms typify ...

Researchers headed by a team at the University of Texas at Dallas’ Center for Advanced Pain Studies (CAPS) have made a fundamental discovery about a key mechanism that enables nervous system ...

In a study published in Nature Immunology on January 6, a research team led by Prof. Qian Youcun from the Shanghai Institute ...

G protein-coupled receptors (GPCRs) are expressed on the surface of cells and regulate a range of important functions. Because they are involved in so many sensory and physiological processes, ...

Studies of signal transduction have yielded a wealth of information about the molecules required to transmit signals from the cell surface to the nucleus. Yet it still remains unknown how a signaling ...

A genetic mutation passed from mother to children in families affected by schizophrenia has now been shown to completely ...

New research combines two powerful imaging techniques to study the complete structure of a common aGPCR, including how its long and complex extracellular region interacts with the transmembrane region ...