A Week 6 NFL betting guide would cover all bases and help make your betting slip a profitable one. Being aware of statistical trends, recent injuries, how weather affects teams and other factors all should be a part of your NFL betting strategy,

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The latest edition of Newsweek Sports Betting tackles Lions vs. Chiefs on Sunday Night Football and checks in on the Bills.

Which NFL teams have the best chances of winning their games on the NFL Week 6 schedule? ESPN Analytics has revealed its Matchup Predictor numbers for the 15 games in the league this week, and they offer some interesting win probabilities.