The research team developed a genetically engineered mouse model carrying a mutation (E3896A) in RyR1, which disrupts its calcium-binding site, effectively disabling CICR while preserving ...

THE myosin crossbridges which project from the thick filaments of striated muscle are known to bend and attach to the thin filaments in the absence of their enzymatic substrate, ATP 1. Huxley and ...

Numerous motor and structural proteins compose a highly ordered structure known as the sarcomere, the basic unit of muscle contraction in heart and skeletal muscles. Sarcomeric myosin heavy chain ...