The mechanistic significance of centrosome aberrations for the induction of chromosomal instability has been a matter of intensive debate as well. On the one hand, it has been proposed that abnormal ...

Centrosomes, which are composed of two centrioles and pericentriolar material, serve as the main microtubule-organizing centre in animal cells. They duplicate once per cell cycle so that each daughter ...

The reproduction, or duplication, of the centrosome is an important event in a cell's preparation for mitosis. We sought to determine if centrosome reproduction is regulated by the synthesis and ...

The centrosome is the organelle responsible for the organization of the cytoskeleton during cell division, an essential function in organisms from yeast to humans. Until now, scientists assumed that ...

Intra-patient genomic heterogeneity of single circulating tumor cells (CTCs) associated to phenotypic CTC heterogeneity in metastatic castrate resistant prostate cancer (mCRPC). SOD2 rs4880 CT/CC ...

Centrosomes are small structures in cells with many essential functions, including roles in cell signaling and in organizing a cell’s cytoskeleton. Centrosome dysfunction contributes to diseases like ...

TROY, N.Y. -- Researchers at Rensselaer Polytechnic Institute, the Marine Biological Laboratory (MBL) in Woods Hole and Louisiana State University (LSU) Health Sciences Center have discovered the ...

Non Adherence to Post Surgery Annual Surveilance Mammogram and Follow Up Among Breast Cancer Survivors in a Tertiary Care Hospital in Malaysia Modern chemotherapeutics frequently suffer from selective ...

Unseen and ongoing, thousands of times every second: to keep a complex organism like humans alive, an immense number of new cells must be continuously produced. Up close, each of these cell divisions ...

One of the proteins required for centrosome clustering is kinesin family member C1 (KIFC1/HSET), and modulation of KIFC1 stability could reduce its activity in cancer cells.

Cold Spring Harbor, N.Y. – Before a cell can divide into two, first it must duplicate its genetic material--the DNA packed in its chromosomes. The two new sets of chromosomes then have to be separated ...

Fella Tamzalit, Diana Tran, Weiyang Jin, Vitaly Boyko, Hisham Bazzi, Ariella Kepecs, Lance C. Kam, Kathryn V. Anderson, Morgan Huse Proceedings of the National ...