Cis-regulatory elements (CREs), including enhancers, silencers, promoters and insulators, play pivotal roles in orchestrating gene regulatory mechanisms that drive complex biological traits. However, ...

Analyzing single-cell RNA sequencing (scRNA-seq) data is crucial for understanding complex biological processes and disease development, but identifying individual cell types within these vast ...

Inter-patient tumor heterogeneity refers to transcriptional differences between cancer cells of different patients. Because of their distinct mutational histories, spatial location and interactions ...

Researchers headed by a team at the University of California, Irvine, Joe C. Wen School of Population & Public Health have built what they suggest is the first cell type-specific gene regulatory ...

A large plasma proteomics study shows that aging patterns in specific cell types may help identify who is more vulnerable to disease and who is more resilient.

Plant immunity research has undergone a transformative shift with the advent of spatial and single-cell technologies, ...

Full-body defense does not always look the way textbooks say it should. In planarian flatworms, a newly identified cell type ...

Neurodegenerative diseases affect more than 57 million people globally. The incidence of these diseases, from Alzheimer's to Parkinson's to ALS and beyond, is expected to double every 20 years. Though ...

scODIN (Optimized Detection and Inference of Names in scRNA-seq data) overview. a, Automatic top-level cell type identification to identify major clusters (CD4 T cells, B cells, monocytes) for further ...