A panelist discusses how tumor heterogeneity (both spatial and temporal) affects molecular testing reliability in ovarian cancer, highlighting that although most biomarkers show little heterogeneity, ...

The capacity of tumors to progress and evade therapeutic intervention is driven largely by their remarkable plasticity and cellular heterogeneity. Our Series on Tumor Heterogeneity and Plasticity ...

Researchers at the UCLA Health Jonsson Comprehensive Cancer Center have developed a new platform that combines 3D bioprinting ...

Lung cancer remains a formidable global health challenge, representing a significant burden on both individuals and healthcare systems 1,2. To address this problem, we utilize the emerging field of ...

Visualization in the UMAP space of samples corresponding to the subtypes ER+ (a), HER2+ (b), and TN (c). The samples were categorized by cancer subtype and integrated. Cells are color-coded according ...

The researchers have developed a novel deep learning framework that integrates high-resolution pathology images with spatial transcriptomics and proteomics to reveal the complex intra-tumor ...

But while heterogeneity is a problem, researchers don't know enough to characterize it: "So far, researchers haven't been able to clearly explain how adjacent cells in a tumor differ from each other, ...

This eBook explores how new approaches are addressing these challenges across the research lifecycle, from discovery through ...

Gene expression signatures in biopsy cores as predictors of coexisting higher-grade disease in Gleason group 1 prostate cancer: Results from the Miami MAST prospective clinical trial. This is an ASCO ...

Researchers developed a platform combining 3D bioprinting, imaging and AI to monitor drug responses in tumor organoids. It ...

Cancer plasticity refers to the remarkable ability of cancer cells to alter their identity, function, and behavior in response to environmental stressors or therapeutic pressures. This dynamic trait ...